Version 5.4
Homo sapiens Protein: NDNF
Summary
InnateDB Protein IDBP-36047.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDNF
Protein Name neuron-derived neurotrophic factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000369014
InnateDB Gene IDBG-36045 (NDNF)
Protein Structure
UniProt Annotation
Function Promotes matrix assembly and cell adhesiveness (By similarity). Promotes neuron migration, growth and survival as well as neurite outgrowth. {ECO:0000250, ECO:0000269PubMed:20969804}.
Subcellular Localization Secreted {ECO:0000269PubMed:20969804}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0001764 neuron migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0016049 cell growth
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
GO:0030198 extracellular matrix organization
GO:0043524 negative regulation of neuron apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR019326 Protein of unknown function DUF2369
PFAM PF00041
PF01108
PF10179
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TB73
PhosphoSite PhosphoSite-Q8TB73
TrEMBL D6RF18
UniProt Splice Variant
Entrez Gene 79625
UniGene Hs.709520
RefSeq NP_078850
HUGO HGNC:26256
OMIM
CCDS CCDS3717
HPRD 08019
IMGT
EMBL AC105254 AK026844 AK289615 AY358821 BC019351 CH471056
GenPept AAH19351 AAQ89180 BAB15573 BAF82304 EAX05266

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca