Version 5.4
Homo sapiens Protein: IL5RA
Summary
InnateDB Protein IDBP-360715.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL5RA
Protein Name interleukin 5 receptor, alpha
Synonyms CD125; CDw125; HSIL5R3; IL5R;
Species Homo sapiens
Ensembl Protein ENSP00000412209
InnateDB Gene IDBG-13590 (IL5RA)
Protein Structure
UniProt Annotation
Function This is the receptor for interleukin-5. The alpha chain binds to IL5.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed on eosinophils and basophils.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004914 interleukin-5 receptor activity
GO:0005515 protein binding
Biological Process
GO:0002437 inflammatory response to antigenic stimulus
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0032674 regulation of interleukin-5 production
GO:0038043 interleukin-5-mediated signaling pathway
GO:0071310 cellular response to organic substance
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003961 Fibronectin, type III
IPR015321 Interleukin-6 receptor alpha, binding
PFAM PF00041
PF01108
PF09240
PRINTS
PIRSF
SMART SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01344
PhosphoSite PhosphoSite-Q01344
TrEMBL C9J6C4
UniProt Splice Variant
Entrez Gene 3568
UniGene Hs.68876
RefSeq NP_783853
HUGO HGNC:6017
OMIM 147851
CCDS CCDS2559
HPRD 00998
IMGT
EMBL AB288090 AC022002 AC024060 AK304256 AY642135 CH471055 M75914 M96651 M96652 X61176 X62156
GenPept AAA36110 AAA59151 AAA59152 AAT45457 BAG49562 BAG65122 CAA43483 CAA44081 EAW63879 EAW63882 EAW63883

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca