InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC6A13

Summary

InnateDB Protein

IDBP-360791.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC6A13

Protein Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

Synonyms

GAT-2; GAT2; GAT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000407104

InnateDB Gene

IDBG-11277 (SLC6A13)

Protein Structure

UniProt Annotation

Function

Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. May also be involved in beta-alanine transport. {ECO:0000269PubMed:17502375, ECO:0000269PubMed:22932902}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22932902}; Multi-pass membrane protein {ECO:0000269PubMed:22932902}.

Disease Associations

Tissue Specificity

Expressed in brain, kidney, lung, liver and testis. {ECO:0000269PubMed:11824941, ECO:0000269PubMed:17502375}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005328	neurotransmitter:sodium symporter activity
GO:0005332	gamma-aminobutyric acid:sodium symporter activity

Biological Process

GO:0006836	neurotransmitter transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0015812	gamma-aminobutyric acid transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome