InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHID1

Summary

InnateDB Protein

IDBP-360935.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHID1

Protein Name

chitinase domain containing 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000416034

InnateDB Gene

IDBG-18558 (CHID1)

Protein Structure

UniProt Annotation

Function

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). {ECO:0000269PubMed:20724479}.

Subcellular Localization

Secreted {ECO:0000269PubMed:16357325}. Lysosome {ECO:0000269PubMed:16357325}.

Disease Associations

Tissue Specificity

Expressed in cells of monocytic, T, B and epithelial origin. {ECO:0000269PubMed:16357325, ECO:0000269PubMed:20724479}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568	chitinase activity
GO:0005515	protein binding
GO:0070492	oligosaccharide binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006032	chitin catabolic process
GO:0045087	innate immune response
GO:1900016	negative regulation of cytokine production involved in inflammatory response

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005764	lysosome
GO:0005770	late endosome
GO:0005802	trans-Golgi network
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome