InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OLFM4

Summary

InnateDB Protein

IDBP-36127.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLFM4

Protein Name

olfactomedin 4

Synonyms

bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD; OLM4; UNQ362;

Species

Homo sapiens

Ensembl Protein

ENSP00000219022

InnateDB Gene

IDBG-36123 (OLFM4)

Protein Structure

UniProt Annotation

Function

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. {ECO:0000269PubMed:16566923, ECO:0000269PubMed:17270022, ECO:0000269PubMed:20724538}.

Subcellular Localization

Secreted, extracellular space. Mitochondrion. Note=Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901). {ECO:0000269PubMed:15059901, ECO:0000269PubMed:16566923, ECO:0000269PubMed:20724538}.

Disease Associations

Tissue Specificity

Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. {ECO:0000269PubMed:11867215, ECO:0000269PubMed:16566923, ECO:0000269PubMed:17270022, ECO:0000269PubMed:20724538}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0045296	cadherin binding

Biological Process

GO:0007155	cell adhesion
GO:0008152	metabolic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050777	negative regulation of immune response
GO:0051260	protein homooligomerization
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0042581	specific granule
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome