Version 5.4
Homo sapiens Protein: SLC17A6
Summary
InnateDB Protein IDBP-36156.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC17A6
Protein Name solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000263160
InnateDB Gene IDBG-36152 (SLC17A6)
Protein Structure
UniProt Annotation
Function Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269PubMed:10820226, ECO:0000269PubMed:11698620}.
Subcellular Localization Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in adult brain. Expressed in amygdala, caudate nucleus, cerebral cortex, frontal lobe, hippocampus, medulla, occipital lobe, putamen, spinal cord, substantia nigra, subthalamic nucleus, temporal lobe and thalamus. {ECO:0000269PubMed:10820226}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005313 L-glutamate transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0001504 neurotransmitter uptake
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0015813 L-glutamate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0008021 synaptic vesicle
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
GO:0043005 neuron projection
Protein Structure and Domains
PDB ID
InterPro IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P2U8
PhosphoSite PhosphoSite-Q9P2U8
TrEMBL
UniProt Splice Variant
Entrez Gene 57084
UniGene Hs.242821
RefSeq NP_065079
HUGO HGNC:16703
OMIM 607563
CCDS CCDS7856
HPRD 10459
IMGT
EMBL AB032435 AC040936 BC069629 BC069640 BC069646 CH471064
GenPept AAH69629 AAH69640 AAH69646 BAA92874 EAW68324

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca