Version 5.4
Homo sapiens Protein: TSPY1
Summary
InnateDB Protein IDBP-361685.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSPY1
Protein Name testis specific protein, Y-linked 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000403304
InnateDB Gene IDBG-545238 (TSPY1)
Protein Structure
UniProt Annotation
Function May be involved in sperm differentiation and proliferation. {ECO:0000269PubMed:8923009}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:8923009}. Nucleus {ECO:0000269PubMed:8923009}. Note=Predominantly cytoplasmic. Also found in nucleus.
Disease Associations Note=TSPY is located in the gonadoblastoma critical region and is preferentially expressed in tumor germ cells of gonadoblastoma specimens. Expression also correlates with testicular seminoma and tumorigenesis of the prostate gland. {ECO:0000269PubMed:10090875, ECO:0000269PubMed:10773691, ECO:0000269PubMed:11173850}.
Tissue Specificity Specifically expressed in testicular tissues. Isoform 1 and isoform 2 are expressed in spermatogonia and spermatocytes. Found in early testicular carcinoma in situ, spermatogonial cells in testicular tissues of 46,X,Y female and in prostate cancer cell lines. {ECO:0000269PubMed:10747295, ECO:0000269PubMed:8923009}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007283 spermatogenesis
GO:0007506 gonadal mesoderm development
GO:0007548 sex differentiation
GO:0008283 cell proliferation
GO:0030154 cell differentiation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR002164 Nucleosome assembly protein (NAP)
PFAM PF00956
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q01534
PhosphoSite PhosphoSite-Q01534
TrEMBL
UniProt Splice Variant
Entrez Gene 728403
UniGene
RefSeq NP_003299
HUGO HGNC:12381
OMIM 480100
CCDS CCDS48205
HPRD 11852
IMGT
EMBL AC006156 AF106331 BC121114 M94893 M98524 M98525 U58096 X06325 X74029
GenPept AAA36570 AAA61238 AAB51693 AAD47421 AAI21115 CAA29640

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca