InnateDB Protein
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IDBP-362005.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TTLL3
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Protein Name
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tubulin tyrosine ligase-like family, member 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000409246
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InnateDB Gene
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IDBG-235749 (TTLL3)
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Protein Structure
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Function |
Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction. {ECO:0000269PubMed:19524510}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0070735
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protein-glycine ligase activity
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GO:0070736
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protein-glycine ligase activity, initiating
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004344
Tubulin-tyrosine ligase/Tubulin polyglutamylase
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PFAM |
PF03133
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y4R7
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PhosphoSite |
PhosphoSite-Q9Y4R7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
26140
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UniGene |
Hs.726435
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RefSeq |
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HUGO |
HGNC:24483
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OMIM |
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CCDS |
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HPRD |
15585
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IMGT |
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EMBL |
AC022382
AF078842
AK023960
AL096725
AL833939
BC098298
BC098361
BC099735
BC105638
BX648175
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GenPept |
AAF23353
AAH98298
AAH98361
AAH99735
AAI05639
BAB14741
CAB46375
CAD38794
CAH10554
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