InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEPT5

Summary

InnateDB Protein

IDBP-362075.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEPT5

Protein Name

septin 5

Synonyms

CDCREL; CDCREL-1; CDCREL1; H5; HCDCREL-1; PNUTL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000394541

InnateDB Gene

IDBG-1395 (SEPT5)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity). {ECO:0000250, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules.

Disease Associations

Tissue Specificity

Expressed at high levels in the CNS, as well as in heart and platelets (at protein level). {ECO:0000269PubMed:12023038, ECO:0000269PubMed:15915442}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000910	cytokinesis
GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0016080	synaptic vesicle targeting
GO:0017157	regulation of exocytosis

Cellular Component

GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0031105	septin complex

Protein Structure and Domains

PDB ID

InterPro

IPR000038 Cell division protein GTP binding
IPR004881 Ribosome biogenesis GTPase RsgA, putative
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00735
PF03193

PRINTS

PIRSF

PIRSF006698

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99719