Version 5.4
Homo sapiens Protein: IL17RE
Summary
InnateDB Protein IDBP-362163.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17RE
Protein Name interleukin 17 receptor E
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000388086
InnateDB Gene IDBG-16793 (IL17RE)
Protein Structure
UniProt Annotation
Function Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. {ECO:0000269PubMed:21993848, ECO:0000269PubMed:21993849}.
Subcellular Localization Isoform 1: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000305}.Isoform 3: Secreted {ECO:0000305}.Isoform 4: Cytoplasm {ECO:0000305}.Isoform 5: Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. {ECO:0000269PubMed:16310341, ECO:0000269PubMed:21993848}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFR9
PhosphoSite PhosphoSite-Q8NFR9
TrEMBL
UniProt Splice Variant
Entrez Gene 132014
UniGene Hs.390823
RefSeq NP_001180309
HUGO HGNC:18439
OMIM 614995
CCDS CCDS54552
HPRD 17143
IMGT
EMBL AF458069 AK074238 AK096793 AK096801 AK314476 AY358451 BC063110 BC137077 BC137078 CH471055
GenPept AAH63110 AAI37078 AAI37079 AAM77573 AAQ88816 BAB85028 BAC04863 BAC04864 BAG37081 EAW64016 EAW64019 EAW64020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca