Version 5.4
Homo sapiens Protein: SLA
Summary
InnateDB Protein IDBP-36258.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLA
Protein Name Src-like-adaptor
Synonyms SLA1; SLAP;
Species Homo sapiens
Ensembl Protein ENSP00000337548
InnateDB Gene IDBG-36256 (SLA)
Protein Structure
UniProt Annotation
Function Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269PubMed:10449770, ECO:0000269PubMed:11696592}.
Subcellular Localization Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with endosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in lung and fetal brain. Weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:9660183}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
Biological Process
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005768 endosome
Protein Structure and Domains
PDB ID
InterPro IPR000980 SH2 domain
IPR001452 SH3 domain
PFAM PF00017
PF14633
PF00018
PF14604
PRINTS PR00401
PR00452
PIRSF
SMART SM00252
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13239
PhosphoSite PhosphoSite-Q13239
TrEMBL E5RK95
UniProt Splice Variant
Entrez Gene 6503
UniGene
RefSeq NP_001039021
HUGO HGNC:10902
OMIM 601099
CCDS CCDS6370
HPRD 03060
IMGT
EMBL AF235100 AF305872 AJ238591 AK297423 AK297519 AK312584 BC007042 CH471060 CR536537 D89077 U30473 U44403
GenPept AAC27662 AAC50357 AAH07042 BAA13758 BAG35478 BAH12578 BAH12602 CAB53536 CAG38774 EAW92159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca