Version 5.4
Homo sapiens Protein: C1orf86
Summary
InnateDB Protein IDBP-362882.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1orf86
Protein Name chromosome 1 open reading frame 86
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000410450
InnateDB Gene IDBG-86132 (C1orf86)
Protein Structure
UniProt Annotation
Function Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. {ECO:0000269PubMed:22266823, ECO:0000269PubMed:22343915, ECO:0000269PubMed:22396592, ECO:0000269PubMed:22705371}.
Subcellular Localization Nucleus. Chromosome. Note=Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0031593 polyubiquitin binding
GO:0043130 ubiquitin binding
GO:0046872 metal ion binding
GO:0070530 K63-linked polyubiquitin binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0019985 translesion synthesis
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0030054 cell junction
GO:0043240 Fanconi anaemia nuclear complex
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6NZ36
PhosphoSite PhosphoSite-Q6NZ36
TrEMBL
UniProt Splice Variant
Entrez Gene 199990
UniGene
RefSeq NP_001269601
HUGO HGNC:26428
OMIM 615183
CCDS
HPRD 08707
IMGT
EMBL AF461903 AK055593 AK126870 AL590822 BC066360 BC078145 BC103992 CH471183
GenPept AAH66360 AAI03993 AAQ04817 BAB70965 BAC86730 EAW56125

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca