Version 5.4
Homo sapiens Protein: TMEM97
Summary
InnateDB Protein IDBP-36302.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM97
Protein Name transmembrane protein 97
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000226230
InnateDB Gene IDBG-36298 (TMEM97)
Protein Structure
UniProt Annotation
Function Plays a role as a regulator of cellular cholesterol homeostasis. {ECO:0000269PubMed:19583955}.
Subcellular Localization Nucleus membrane. Rough endoplasmic reticulum. Cell membrane. Lysosome. Membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}. Note=Localized in sterol- depleted cells at cell membrane and in lysosomes.
Disease Associations
Tissue Specificity Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells and meningioma cancers. Expressed in ovarian cancer; expression is reduced relative to OSE cells. {ECO:0000269PubMed:15375745, ECO:0000269PubMed:18070364, ECO:0000269PubMed:7694637}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001558 regulation of cell growth
GO:0042632 cholesterol homeostasis
Cellular Component
GO:0005764 lysosome
GO:0005791 rough endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID
InterPro IPR016964 Transmembrane protein 6/97
PFAM PF10914
PRINTS
PIRSF PIRSF031032
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5BJF2
PhosphoSite PhosphoSite-Q5BJF2
TrEMBL Q86XC5
UniProt Splice Variant
Entrez Gene 27346
UniGene Hs.596162
RefSeq NP_055388
HUGO HGNC:28106
OMIM 612912
CCDS CCDS11226
HPRD 14343
IMGT
EMBL AC002094 AK293331 AK299511 BC045655 BC091504 L19183
GenPept AAA16188 AAH45655 AAH91504 BAG56847 BAG61464

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca