InnateDB Protein
|
IDBP-363618.5
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
SCG5
|
Protein Name
|
secretogranin V (7B2 protein)
|
Synonyms
|
7B2; P7B2; SGNE1; SgV;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000388560
|
InnateDB Gene
|
IDBG-5178 (SCG5)
|
Protein Structure
|
|
Function |
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. {ECO:0000269PubMed:7913882}.
|
Subcellular Localization |
Secreted. Note=Neuroendocrine and endocrine secretory granules.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR007945
Neuroendocrine 7B2 precursor
|
PFAM |
PF05281
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P05408
|
PhosphoSite |
PhosphoSite-
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
6447
|
UniGene |
Hs.156540
|
RefSeq |
NP_003011
|
HUGO |
HGNC:10816
|
OMIM |
173120
|
CCDS |
CCDS45208
|
HPRD |
01410
|
IMGT |
|
EMBL |
AJ290438
AJ290439
AJ290440
AJ290441
AJ290442
BC005349
BC093053
CH471125
CR541824
Y00757
|
GenPept |
AAH05349
AAH93053
CAA68726
CAB90397
CAG46623
EAW92262
|
|
|