Version 5.4
Homo sapiens Protein: TLE6
Summary
InnateDB Protein IDBP-363621.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TLE6
Protein Name transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000406893
InnateDB Gene IDBG-16586 (TLE6)
Protein Structure
UniProt Annotation
Function As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions. {ECO:0000250}.
Subcellular Localization Cytoplasm. Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR009146 Groucho/transducin-like enhancer
IPR017986 WD40-repeat-containing domain
PFAM PF00400
PRINTS PR01850
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H808
PhosphoSite PhosphoSite-Q9H808
TrEMBL
UniProt Splice Variant
Entrez Gene 79816
UniGene Hs.334507
RefSeq NP_079036
HUGO HGNC:30788
OMIM 612399
CCDS CCDS12100
HPRD 18195
IMGT
EMBL AC006277 AC007766 AK024071 BC007215 BC020206
GenPept AAH07215 AAH20206 BAB14815

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca