Version 5.4
Homo sapiens Protein: TOP3B
Summary
InnateDB Protein IDBP-364028.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP3B
Protein Name topoisomerase (DNA) III beta
Synonyms TOP3B1;
Species Homo sapiens
Ensembl Protein ENSP00000408282
InnateDB Gene IDBG-2166 (TOP3B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
Biological Process
GO:0006265 DNA topological change
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000380 DNA topoisomerase, type IA
IPR003602 DNA topoisomerase, type IA, DNA-binding domain
IPR013497 DNA topoisomerase, type IA, central
IPR023405 DNA topoisomerase, type IA, core domain
PFAM PF01131
PRINTS PR00417
PIRSF
SMART SM00437
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL B3KU89
UniProt Splice Variant
Entrez Gene 8940
UniGene Hs.436401
RefSeq XP_006724414
HUGO HGNC:11993
OMIM 603582
CCDS
HPRD 04662
IMGT
EMBL AK096695
GenPept BAG53351

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca