InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC13A5

Summary

InnateDB Protein

IDBP-364484.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC13A5

Protein Name

solute carrier family 13 (sodium-dependent citrate transporter), member 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000406220

InnateDB Gene

IDBG-22524 (SLC13A5)

Protein Structure

UniProt Annotation

Function

High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. {ECO:0000269PubMed:12445824}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed most predominantly in the liver, with moderate expression detectable in the brain and testis. {ECO:0000269PubMed:12445824}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005343	organic acid:sodium symporter activity
GO:0015137	citrate transmembrane transporter activity
GO:0015141	succinate transmembrane transporter activity
GO:0015142	tricarboxylic acid transmembrane transporter activity
GO:0017153	sodium:dicarboxylate symporter activity

Biological Process

GO:0006814	sodium ion transport
GO:0006842	tricarboxylic acid transport
GO:0015744	succinate transport
GO:0015746	citrate transport
GO:0035674	tricarboxylic acid transmembrane transport
GO:0055085	transmembrane transport