InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RX6

Summary

InnateDB Protein

IDBP-364552.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX6

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 6

Synonyms

P2RXL1; P2X6; P2XM;

Species

Homo sapiens

Ensembl Protein

ENSP00000416193

InnateDB Gene

IDBG-1914 (P2RX6)

Protein Structure

UniProt Annotation

Function

Receptor for ATP that acts as a ligand-gated ion channel. {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly in skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015267	channel activity
GO:0042802	identical protein binding

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006936	muscle contraction
GO:0007165	signal transduction
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0051260	protein homooligomerization
GO:0051291	protein heterooligomerization
GO:0055085	transmembrane transport

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0030054	cell junction
GO:0043025	neuronal cell body
GO:0043197	dendritic spine