Version 5.4
Homo sapiens Protein: CAND2
Summary
InnateDB Protein IDBP-364655.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAND2
Protein Name cullin-associated and neddylation-dissociated 2 (putative)
Synonyms TIP120B; Tp120b;
Species Homo sapiens
Ensembl Protein ENSP00000387641
InnateDB Gene IDBG-19418 (CAND2)
Protein Structure
UniProt Annotation
Function Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in epididymis (at protein level). {ECO:0000269PubMed:20736409}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR000357 HEAT
IPR013932 TATA-binding protein interacting (TIP20)
IPR016024 Armadillo-type fold
PFAM PF02985
PF08623
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75155
PhosphoSite PhosphoSite-O75155
TrEMBL
UniProt Splice Variant
Entrez Gene 23066
UniGene Hs.343664
RefSeq NP_001155971
HUGO HGNC:30689
OMIM 610403
CCDS CCDS54554
HPRD
IMGT
EMBL AB014567 AC034198 BC136592 GU727621
GenPept AAI36593 ADU87623 BAA31642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca