InnateDB Protein
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IDBP-36493.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC9A5
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Protein Name
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solute carrier family 9 (sodium/hydrogen exchanger), member 5
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Synonyms
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NHE5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000299798
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InnateDB Gene
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IDBG-36491 (SLC9A5)
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Protein Structure
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Function |
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane; Multi-pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, testis, spleen, and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
|
Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015299
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solute:proton antiporter activity
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GO:0015385
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sodium:proton antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004709
Na+/H+ exchanger
IPR006153
Cation/H+ exchanger
IPR018410
Na+/H+ exchanger, isoforms 3/5
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PFAM |
PF00999
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PRINTS |
PR01084
PR01087
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q14940
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PhosphoSite |
PhosphoSite-Q14940
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
6553
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UniGene |
Hs.439650
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RefSeq |
NP_004585
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HUGO |
HGNC:11078
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OMIM |
600477
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CCDS |
CCDS42178
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HPRD |
02723
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IMGT |
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EMBL |
AF111173
BC142671
CH471092
U08607
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GenPept |
AAA87678
AAC98696
AAI42672
EAW83114
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