InnateDB Protein
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IDBP-365025.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CABLES1
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Protein Name
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Cdk5 and Abl enzyme substrate 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000413851
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InnateDB Gene
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IDBG-1535 (CABLES1)
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Protein Structure
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Function |
Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in breast, pancreas, colon, head and neck (at protein level). Strongly decreased in more than half of cases of atypical endometrial hyperplasia and in more than 90% of endometrial cancers. {ECO:0000269PubMed:11585773, ECO:0000269PubMed:14729625}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0016538
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cyclin-dependent protein serine/threonine kinase regulator activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006671
Cyclin, N-terminal
IPR012388
Cdk5/c-Abl linker protein Cables
IPR013763
Cyclin-like
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PFAM |
PF00134
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PRINTS |
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PIRSF |
PIRSF025798
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TDN4
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PhosphoSite |
PhosphoSite-Q8TDN4
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TrEMBL |
A0A024RC20
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UniProt Splice Variant |
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Entrez Gene |
91768
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UniGene |
Hs.11108
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RefSeq |
NP_612384
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HUGO |
HGNC:25097
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OMIM |
609194
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CCDS |
CCDS42418
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HPRD |
16461
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IMGT |
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EMBL |
AC011731
AC105247
AF348525
AK093243
AK296407
BC004124
BC037218
CH471088
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GenPept |
AAH04124
AAH37218
AAL83906
BAC04107
BAG59072
EAX01147
EAX01148
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