Version 5.4
Homo sapiens Protein: TSLP
Summary
InnateDB Protein IDBP-36513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSLP
Protein Name thymic stromal lymphopoietin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000339804
InnateDB Gene IDBG-36507 (TSLP)
Protein Structure
UniProt Annotation
Function Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells. {ECO:0000269PubMed:11418668, ECO:0000269PubMed:11480573, ECO:0000269PubMed:17242164}.
Subcellular Localization Secreted {ECO:0000269PubMed:11418668}.
Disease Associations
Tissue Specificity Expressed in a number of tissues including heart, liver and prostate. {ECO:0000269PubMed:11480573}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 8 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q969D9
PhosphoSite PhosphoSite-
TrEMBL Q96AU7
UniProt Splice Variant
Entrez Gene 85480
UniGene Hs.612063
RefSeq NP_149024
HUGO HGNC:30743
OMIM 607003
CCDS CCDS4101
HPRD 06108
IMGT
EMBL AC008572 AF338732 AY037115 BC016720 BC022894 BC040592 CH471086
GenPept AAH16720 AAH22894 AAH40592 AAK60617 AAK67490 EAW49038

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca