Version 5.4
Homo sapiens Protein: CLDN7
Summary
InnateDB Protein IDBP-365253.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLDN7
Protein Name claudin 7
Synonyms CEPTRL2; claudin-1; CLDN-7; CPETRL2; Hs.84359;
Species Homo sapiens
Ensembl Protein ENSP00000396638
InnateDB Gene IDBG-24056 (CLDN7)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space. {ECO:0000250}.
Subcellular Localization Cell membrane; Multi-pass membrane protein. Lateral cell membrane. Cell junction, tight junction. Note=Co- localizes with EPCAM at the lateral cell membrane and tight junction.
Disease Associations
Tissue Specificity Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. {ECO:0000269PubMed:12673207, ECO:0000269PubMed:14502431}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
GO:0016328 lateral plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003552 Claudin-7
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01381
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95471
PhosphoSite PhosphoSite-O95471
TrEMBL K7EP40
UniProt Splice Variant
Entrez Gene 1366
UniGene Hs.733833
RefSeq NP_001171951
HUGO HGNC:2049
OMIM 609131
CCDS CCDS11096
HPRD 07633
IMGT
EMBL AC003688 AF093823 AJ011497 AK313958 BC001055 BC071844 BT006829 CH471108
GenPept AAH01055 AAH71844 AAP35475 AAP97219 BAG36674 CAA09626 EAW90228 EAW90229

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca