InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGTR1

Summary

InnateDB Protein

IDBP-365534.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGTR1

Protein Name

angiotensin II receptor, type 1

Synonyms

AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000398832

InnateDB Gene

IDBG-60289 (AGTR1)

Protein Structure

UniProt Annotation

Function

Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269PubMed:16116425}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Liver, lung, adrenal and adrenocortical adenomas.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0031711	bradykinin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001822	kidney development
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007266	Rho protein signal transduction
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010873	positive regulation of cholesterol esterification
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032430	positive regulation of phospholipase A2 activity
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0034374	low-density lipoprotein particle remodeling
GO:0035813	regulation of renal sodium excretion
GO:0038166	angiotensin-activated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042312	regulation of vasodilation
GO:0050727	regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326	cell chemotaxis
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000190 Angiotensin II receptor type 1
IPR000248 Angiotensin II receptor family
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR000496 Bradykinin receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00635
PR00241
PR00237
PR00657
PR00425

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30556