Version 5.4
Homo sapiens Protein: AGBL5
Summary
InnateDB Protein IDBP-36568.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGBL5
Protein Name ATP/GTP binding protein-like 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353249
InnateDB Gene IDBG-36560 (AGBL5)
Protein Structure
UniProt Annotation
Function Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6 (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
GO:0015631 tubulin binding
Biological Process
GO:0006508 proteolysis
GO:0035608 protein deglutamylation
GO:0035611 protein branching point deglutamylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
PFAM PF00246
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NDL9
PhosphoSite PhosphoSite-Q8NDL9
TrEMBL C9JTY1
UniProt Splice Variant
Entrez Gene 60509
UniGene Hs.138207
RefSeq NP_068603
HUGO HGNC:26147
OMIM 615900
CCDS CCDS1732
HPRD 07968
IMGT
EMBL AC013403 AC013472 AK023398 AK025492 AK302091 AL833844 BC007415 BC018584 BC131498 CH471053
GenPept AAH07415 AAI31499 AAX93164 AAY14655 BAB14560 BAB15151 BAH13623 CAD38704 EAX00649 EAX00651 EAX00652 EAX00653

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca