InnateDB Protein
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IDBP-36594.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLVAP
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Protein Name
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plasmalemma vesicle associated protein
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000252590
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InnateDB Gene
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IDBG-36592 (PLVAP)
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Protein Structure
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Function |
Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability. {ECO:0000269PubMed:15155804}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane, caveola {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Membrane- associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium. {ECO:0000269PubMed:11401446, ECO:0000269PubMed:15971170}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009538
PV-1
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PFAM |
PF06637
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BX97
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PhosphoSite |
PhosphoSite-Q9BX97
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83483
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UniGene |
Hs.107125
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RefSeq |
NP_112600
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HUGO |
HGNC:13635
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OMIM |
607647
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CCDS |
CCDS32952
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HPRD |
09626
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IMGT |
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EMBL |
AF326591
AF348827
AK074054
AK096030
AL834363
BC050365
BC056414
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GenPept |
AAH50365
AAH56414
AAK11226
AAK20040
BAB84880
BAC04681
CAD39027
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