Version 5.4
Homo sapiens Protein: C15orf23
Summary
InnateDB Protein IDBP-366075.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C15orf23
Protein Name chromosome 15 open reading frame 23
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000393001
InnateDB Gene IDBG-6303 (C15orf23)
Protein Structure
UniProt Annotation
Function Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. {ECO:0000269PubMed:19667759, ECO:0000269PubMed:21402792, ECO:0000269PubMed:22110139}.
Subcellular Localization Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Note=Colocalizes with microtubules around centrosomes in prophase and with the mitotic spindle at prometaphase and metaphase. From late prometaphase to anaphase, is highly concentrated on kinetochores. Located at the kinetochore-microtubule interface. The astrin (SPAG5)-kinastrin (SKAP) complex localizes to the microtubule plus ends.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0007051 spindle organization
GO:0007059 chromosome segregation
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
GO:0035371 microtubule plus-end
GO:0072686 mitotic spindle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y448
PhosphoSite PhosphoSite-Q9Y448
TrEMBL B4DP18
UniProt Splice Variant
Entrez Gene 90417
UniGene Hs.659314
RefSeq NP_001136234
HUGO HGNC:30767
OMIM 614718
CCDS CCDS45227
HPRD 12669
IMGT
EMBL AC013356 AK298156 AK301887 AY652615 BC004543 BC014060 BC045739 BC064344 BC107802 BC118559 BC118639 CR602848 CR611451 U81002
GenPept AAD24201 AAH04543 AAH14060 AAH45739 AAH64344 AAI07803 AAI18560 AAI18640 AAT66172 BAG60430 BAG63319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca