InnateDB Protein
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IDBP-366630.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CHAC1
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Protein Name
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ChaC, cation transport regulator homolog 1 (E. coli)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000398105
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InnateDB Gene
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IDBG-6874 (CHAC1)
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Protein Structure
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Function |
Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. {ECO:0000269PubMed:19109178, ECO:0000269PubMed:22445366}.
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Subcellular Localization |
Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269PubMed:19109178}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006986
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response to unfolded protein
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GO:0007219
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Notch signaling pathway
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GO:0010955
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negative regulation of protein processing
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GO:0022008
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neurogenesis
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GO:0045746
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negative regulation of Notch signaling pathway
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GO:0070059
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intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Cellular Component |
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PDB ID |
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InterPro |
IPR006840
ChaC-like protein
IPR013024
Butirosin biosynthesis, BtrG-like
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PFAM |
PF04752
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BUX1
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PhosphoSite |
PhosphoSite-Q9BUX1
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TrEMBL |
H0YK90
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UniProt Splice Variant |
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Entrez Gene |
79094
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UniGene |
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RefSeq |
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HUGO |
HGNC:28680
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OMIM |
614587
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CCDS |
CCDS10070
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HPRD |
14634
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IMGT |
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EMBL |
AC020661
AY702027
BC001683
BC001847
BC019625
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GenPept |
AAH01683
AAH01847
AAH19625
AAW23972
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