InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHAC1

Summary

InnateDB Protein

IDBP-366631.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHAC1

Protein Name

ChaC, cation transport regulator homolog 1 (E. coli)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000395466

InnateDB Gene

IDBG-6874 (CHAC1)

Protein Structure

UniProt Annotation

Function

Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. {ECO:0000269PubMed:19109178, ECO:0000269PubMed:22445366}.

Subcellular Localization

Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269PubMed:19109178}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005515	protein binding

Biological Process

GO:0006986	response to unfolded protein
GO:0007219	Notch signaling pathway
GO:0010955	negative regulation of protein processing
GO:0022008	neurogenesis
GO:0045746	negative regulation of Notch signaling pathway
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress