Version 5.4
| Homo sapiens Protein: CLEC2D | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-366655.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | CLEC2D | ||||||||
| Protein Name | C-type lectin domain family 2, member D | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000413045 | ||||||||
| InnateDB Gene | IDBG-17917 (CLEC2D) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Receptor for KLRB1 that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Inhibits bone resorption. Modulates the release of interferon- gamma. Binds high molecular weight sulfated glycosaminoglycans. {ECO:0000269PubMed:14753741, ECO:0000269PubMed:15104121, ECO:0000269PubMed:16339513}. | ||||||||
| Subcellular Localization | Cell membrane; Single-pass type II membrane protein. Cell surface.Isoform 2: Endoplasmic reticulum.Isoform 4: Endoplasmic reticulum. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Detected in peripheral blood leukocytes, osteoblasts, lymph node, thymus and spleen. Isoform 1, isoform 2 and isoform 4 are expressed in T- and B-lymphocytes, and at lower levels in NK cells. They are also expressed in B-cell lines and LPS-matured monocyte-derived dendritic cells. {ECO:0000269PubMed:10541800, ECO:0000269PubMed:20843815}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR001304
C-type lectin IPR008646 Herpesvirus UL45-like IPR016187 C-type lectin fold |
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| PFAM |
PF00059
PF05473 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00034
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q9UHP7 | ||||||||
| PhosphoSite | PhosphoSite-Q9UHP7 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 29121 | ||||||||
| UniGene | |||||||||
| RefSeq | |||||||||
| HUGO | HGNC:14351 | ||||||||
| OMIM | 605659 | ||||||||
| CCDS | |||||||||
| HPRD | 16134 | ||||||||
| IMGT | |||||||||
| EMBL | AC007068 AC010186 AF133299 AF285087 AF285088 AF285089 AY144606 BC019883 CH471094 FN813349 FN813350 FN813351 | ||||||||
| GenPept | AAF22159 AAG00514 AAG00515 AAG00516 AAH19883 AAN59996 CBL81070 CBL81071 CBL81072 EAW96114 | ||||||||