Version 5.4
Homo sapiens Protein: ENOX1
Summary
InnateDB Protein IDBP-366691.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENOX1
Protein Name ecto-NOX disulfide-thiol exchanger 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000415054
InnateDB Gene IDBG-28615 (ENOX1)
Protein Structure
UniProt Annotation
Function Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock. {ECO:0000269PubMed:11360993, ECO:0000269PubMed:12565167, ECO:0000269PubMed:17027975}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:11360993}. Secreted, extracellular space {ECO:0000269PubMed:11360993}. Note=Extracellular and plasma membrane-associated.
Disease Associations
Tissue Specificity Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0048511 rhythmic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TC92
PhosphoSite PhosphoSite-Q8TC92
TrEMBL A0A024RDX6
UniProt Splice Variant
Entrez Gene 55068
UniGene Hs.128258
RefSeq NP_001121087
HUGO HGNC:25474
OMIM 610914
CCDS CCDS9389
HPRD 07644
IMGT
EMBL AK000956 AL138823 AL607148 AL627430 AY513282 BC024178 CH471075 EF432052
GenPept AAH24178 AAT08035 ABO28524 BAA91442 CAH70584 CAH72199 CAI16283 EAX08692 EAX08693 EAX08694 EAX08695

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca