Version 5.4
Homo sapiens Protein: BAG4
Summary
InnateDB Protein IDBP-366982.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAG4
Protein Name BCL2-associated athanogene 4
Synonyms BAG-4; SODD;
Species Homo sapiens
Ensembl Protein ENSP00000393298
InnateDB Gene IDBG-17465 (BAG4)
Protein Structure
UniProt Annotation
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria. {ECO:0000250, ECO:0000269PubMed:24270810}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 44 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0044822 poly(A) RNA binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR003103 BAG domain
PFAM PF02179
PRINTS
PIRSF
SMART SM00264
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O95429
PhosphoSite PhosphoSite-O95429
TrEMBL
UniProt Splice Variant
Entrez Gene 9530
UniGene Hs.628792
RefSeq NP_001191807
HUGO HGNC:940
OMIM 603884
CCDS CCDS56533
HPRD 04861
IMGT
EMBL AC084024 AF095194 AF111116 AK304072 BC038505
GenPept AAD05226 AAD16123 AAH38505 BAG64979

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca