Version 5.4
Homo sapiens Protein: KHDRBS3
Summary
InnateDB Protein IDBP-36702.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KHDRBS3
Protein Name KH domain containing, RNA binding, signal transduction associated 3
Synonyms Etle; etoile; SALP; SLM-2; SLM2; T-STAR; TSTAR;
Species Homo sapiens
Ensembl Protein ENSP00000348108
InnateDB Gene IDBG-36700 (KHDRBS3)
Protein Structure
UniProt Annotation
Function RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA- binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. {ECO:0000269PubMed:10564820, ECO:0000269PubMed:11741900, ECO:0000269PubMed:15901763}.
Subcellular Localization Nucleus {ECO:0000269PubMed:10332027, ECO:0000269PubMed:15901763}. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
Disease Associations
Tissue Specificity Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis. {ECO:0000269PubMed:10077576, ECO:0000269PubMed:10332027, ECO:0000269PubMed:10564820}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0017124 SH3 domain binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF00013
PF13014
PRINTS
PIRSF
SMART SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75525
PhosphoSite PhosphoSite-O75525
TrEMBL
UniProt Splice Variant
Entrez Gene 10656
UniGene Hs.729205
RefSeq NP_006549
HUGO HGNC:18117
OMIM 610421
CCDS CCDS6374
HPRD 10007
IMGT
EMBL AF051321 AF051322 AF069681 BC032606 BC068536
GenPept AAC24857 AAC99294 AAC99295 AAH32606 AAH68536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca