InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC27A1

Summary

InnateDB Protein

IDBP-36713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC27A1

Protein Name

solute carrier family 27 (fatty acid transporter), member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000252595

InnateDB Gene

IDBG-36711 (SLC27A1)

Protein Structure

UniProt Annotation

Function

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:12235169}; Single-pass membrane protein {ECO:0000269PubMed:12235169}. Endomembrane system {ECO:0000269PubMed:12235169}; Single-pass membrane protein {ECO:0000269PubMed:12235169}. Cytoplasm {ECO:0000250}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. {ECO:0000269PubMed:10873384}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003824	catalytic activity
GO:0015245	fatty acid transporter activity
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0001579	medium-chain fatty acid transport
GO:0006631	fatty acid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006655	phosphatidylglycerol biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006659	phosphatidylserine biosynthetic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0008152	metabolic process
GO:0009409	response to cold
GO:0015908	fatty acid transport
GO:0015909	long-chain fatty acid transport
GO:0031652	positive regulation of heat generation
GO:0032049	cardiolipin biosynthetic process
GO:0032868	response to insulin
GO:0033211	adiponectin-activated signaling pathway
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0071072	negative regulation of phospholipid biosynthetic process
GO:0071902	positive regulation of protein serine/threonine kinase activity