InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EMILIN1

Summary

InnateDB Protein

IDBP-36746.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EMILIN1

Protein Name

elastin microfibril interfacer 1

Synonyms

EMI; EMILIN; gp115;

Species

Homo sapiens

Ensembl Protein

ENSP00000369677

InnateDB Gene

IDBG-36744 (EMILIN1)

Protein Structure

UniProt Annotation

Function

May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity.

Subcellular Localization

Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils.

Disease Associations

Tissue Specificity

Distributed in tissues where resilience and elastic recoil are prominent. Highest levels in the adult small intestine, aorta, lung, uterus, and appendix and in the fetal spleen, kidney, lung, and heart; intermediate expression was detected in adult liver, ovary, colon, stomach, lymph node and spleen; adult heart, bladder, prostate, adrenal gland, mammary gland, placenta and kidney showed low expression whereas a series of other adult tissues, including skeletal muscle and different regions of adult brain show no expression. {ECO:0000269PubMed:11278945}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030023	extracellular matrix constituent conferring elasticity
GO:0042802	identical protein binding

Biological Process

GO:0007155	cell adhesion
GO:0010811	positive regulation of cell-substrate adhesion
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005581	collagen trimer
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome