InnateDB Protein
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IDBP-367491.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SGOL1
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Protein Name
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shugoshin-like 1 (S. pombe)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000410458
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InnateDB Gene
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IDBG-21863 (SGOL1)
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Protein Structure
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Function |
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. {ECO:0000269PubMed:15604152, ECO:0000269PubMed:15723797, ECO:0000269PubMed:15737064, ECO:0000269PubMed:16580887, ECO:0000269PubMed:17617734, ECO:0000269PubMed:17621308, ECO:0000269PubMed:18331714}.
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Subcellular Localization |
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. During prometaphase, it localizes to a single focus, while at metaphase, it localizes to 2 spots corresponding to the 2 centromeres. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Localizes to the inner kinetochore from prophase to early metaphase. Colocalizes with NEK2 and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Highly expressed in testis. Expressed in lung, small intestine, breast, liver and placenta. Strongly overexpressed in 90% of breast cancers tested. {ECO:0000269PubMed:12747765}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
36
[view]
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Protein-Protein |
35
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011515
Shugoshin, C-terminal
IPR011516
Shugoshin, N-terminal
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PFAM |
PF07557
PF07558
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5FBB7
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PhosphoSite |
PhosphoSite-Q5FBB7
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TrEMBL |
B5BUA4
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UniProt Splice Variant |
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Entrez Gene |
151648
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UniGene |
Hs.105153
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RefSeq |
NP_001186180
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HUGO |
HGNC:25088
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OMIM |
609168
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CCDS |
CCDS46773
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HPRD |
12377
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IMGT |
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EMBL |
AB187577
AB187578
AB187579
AB187580
AB187581
AB187582
AB190994
AB193056
AB193057
AB193058
AB193059
AB193060
AB193061
AB193062
AB193063
AB193064
AB193065
AB193066
AB451340
AB451489
AF308299
BC001339
BC017867
BC032696
CH471055
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GenPept |
AAG48266
AAH01339
AAH17867
AAH32696
BAD89587
BAD89588
BAD89589
BAD89590
BAD89591
BAD89592
BAD91318
BAD95529
BAD95530
BAD95531
BAD95532
BAD95533
BAD95534
BAD95535
BAD95536
BAD95537
BAD95538
BAD95539
BAG70154
BAG70303
EAW64307
EAW64308
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