Homo sapiens Protein: MOG | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-367549.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | MOG | ||||||||||||||||||||||
Protein Name | myelin oligodendrocyte glycoprotein | ||||||||||||||||||||||
Synonyms | BTN6; BTNL11; MOGIG2; NRCLP7; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000410866 | ||||||||||||||||||||||
InnateDB Gene | IDBG-73515 (MOG) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Isoform 1: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.Isoform 5: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.Isoform 2: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 3: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 4: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 6: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 7: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 8: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.Isoform 9: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. | ||||||||||||||||||||||
Disease Associations | Narcolepsy 7 (NRCLP7) [MIM:614250]: Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye- movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. {ECO:0000269PubMed:21907016}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||
Tissue Specificity | Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR003596
Immunoglobulin V-set, subgroup IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013106 Immunoglobulin V-set domain IPR016663 Myelin-oligodendrocyte glycoprotein |
||||||||||||||||||||||
PFAM |
PF07686
|
||||||||||||||||||||||
PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF016522
|
||||||||||||||||||||||
SMART |
SM00406
SM00409 |
||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q16653 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q16653 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 4340 | ||||||||||||||||||||||
UniGene | Hs.141308 | ||||||||||||||||||||||
RefSeq | NP_996535 | ||||||||||||||||||||||
HUGO | HGNC:7197 | ||||||||||||||||||||||
OMIM | 159465 | ||||||||||||||||||||||
CCDS | CCDS47394 | ||||||||||||||||||||||
HPRD | 11831 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK312892 AL050328 AL645936 AL662826 AL669813 AL929591 AY566847 AY566853 BX120002 BX927250 CH471081 CR388408 CR759766 CR936483 U18798 U18799 U18800 U18801 U18803 U18840 U18843 U64564 U64565 U64566 U64567 U64568 U64569 U64570 U64571 X74511 Z48051 | ||||||||||||||||||||||
GenPept | AAB08088 AAB08089 AAB08090 AAB08091 AAB08092 AAB08093 AAB08094 AAB08095 AAB36870 AAC50361 AAC50362 AAC50876 AAC50877 AAC50878 AAC50879 AAU09338 AAU09343 BAG35739 CAA52617 CAA88109 CAB89267 CAB89268 CAB89269 CAB89270 CAB89271 CAI17395 CAI17396 CAI17397 CAI17400 CAI17636 CAI17637 CAI18020 CAI18021 CAI18022 CAI18023 CAI18024 CAI41911 CAI41914 CAI41917 CAI95560 CAI95564 CAI95565 CAI95568 CAM25818 CAQ06614 CAQ08208 CAQ08210 CAQ08212 CAQ08213 CAQ10086 CAQ10088 CAQ10090 CAQ10091 CAQ10709 CAQ10711 CAQ10713 CAQ10714 EAX03213 EAX03214 EAX03217 | ||||||||||||||||||||||