InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G4B

Summary

InnateDB Protein

IDBP-367756.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G4B

Protein Name

phospholipase A2, group IVB (cytosolic)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000396045

InnateDB Gene

IDBG-402144 (PLA2G4B)

Protein Structure

UniProt Annotation

Function

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A. Isoform 3 has calcium-dependent activity against palmitoyl-arachidonyl-phosphatidylethanolamine and low level lysophospholipase activity but no activity against phosphatidylcholine. Isoform 5 does have activity against phosphatidylcholine. {ECO:0000269PubMed:10085124, ECO:0000269PubMed:10358058, ECO:0000269PubMed:16617059}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:16617059}.Isoform 3: Mitochondrion membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at higher level in brain, heart, liver, cerebellum and pancreas. Isoform 3 is widely expressed. {ECO:0000269PubMed:10085124, ECO:0000269PubMed:10358058, ECO:0000269PubMed:16617059}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004622	lysophospholipase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006654	phosphatidic acid biosynthetic process
GO:0006954	inflammatory response
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007567	parturition
GO:0008152	metabolic process
GO:0009395	phospholipid catabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019722	calcium-mediated signaling
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036150	phosphatidylserine acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0046475	glycerophospholipid catabolic process