InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PCBP2

Summary

InnateDB Protein

IDBP-36777.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCBP2

Protein Name

poly(rC) binding protein 2

Synonyms

hnRNP-E2; HNRNPE2; HNRPE2;

Species

Homo sapiens

Ensembl Protein

ENSP00000352228

InnateDB Gene

IDBG-36771 (PCBP2)

Protein Structure

UniProt Annotation

Function

Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation. {ECO:0000269PubMed:19881509}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19029303}. Cytoplasm {ECO:0000269PubMed:19029303}. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.

Disease Associations

Tissue Specificity

Detected in all tissues examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	83 [view]
Protein-Protein	80 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0016071	mRNA metabolic process
GO:0032480	negative regulation of type I interferon production
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0050687	negative regulation of defense response to virus
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0070062	extracellular vesicular exosome