Version 5.4
Homo sapiens Protein: SPATA18
Summary
InnateDB Protein IDBP-367840.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPATA18
Protein Name spermatogenesis associated 18 homolog (rat)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000415309
InnateDB Gene IDBG-18160 (SPATA18)
Protein Structure
UniProt Annotation
Function Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. {ECO:0000269PubMed:21264221, ECO:0000269PubMed:21264228, ECO:0000269PubMed:22292033}.
Subcellular Localization Cytoplasm. Mitochondrion outer membrane. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0035694 mitochondrial protein catabolic process
GO:0035695 mitochondrion degradation by induced vacuole formation
Cellular Component
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TC71
PhosphoSite PhosphoSite-Q8TC71
TrEMBL
UniProt Splice Variant
Entrez Gene 132671
UniGene Hs.599512
RefSeq NP_001284537
HUGO HGNC:29579
OMIM 612814
CCDS CCDS75124
HPRD 14050
IMGT
EMBL AB465501 AB465502 AC093858 AK098625 AK304386 BC025396 BC037886 CH471057
GenPept AAH25396 AAH37886 BAC05356 BAG65222 BAJ53738 BAJ53739 EAX05433

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca