InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELOVL7

Summary

InnateDB Protein

IDBP-368281.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELOVL7

Protein Name

ELOVL fatty acid elongase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000402634

InnateDB Gene

IDBG-22899 (ELOVL7)

Protein Structure

UniProt Annotation

Function

Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. {ECO:0000269PubMed:19826053, ECO:0000269PubMed:20937905, ECO:0000269PubMed:21959040}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.

Disease Associations

Tissue Specificity

Expressed in most tissues except heart and skeletal muscle. {ECO:0000269PubMed:20937905}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity

Biological Process

GO:0006633	fatty acid biosynthetic process
GO:0019367	fatty acid elongation, saturated fatty acid
GO:0019432	triglyceride biosynthetic process
GO:0034626	fatty acid elongation, polyunsaturated fatty acid
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process
GO:0042761	very long-chain fatty acid biosynthetic process
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process