InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OXSM

Summary

InnateDB Protein

IDBP-368290.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXSM

Protein Name

3-oxoacyl-ACP synthase, mitochondrial

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000411303

InnateDB Gene

IDBG-22740 (OXSM)

Protein Structure

UniProt Annotation

Function

May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. {ECO:0000269PubMed:15668256}.

Subcellular Localization

Mitochondrion {ECO:0000269PubMed:15668256}.

Disease Associations

Tissue Specificity

Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria. {ECO:0000269PubMed:15668256}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004315	3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0016740	transferase activity

Biological Process

GO:0006637	acyl-CoA metabolic process
GO:0008152	metabolic process
GO:0051790	short-chain fatty acid biosynthetic process
GO:0051792	medium-chain fatty acid biosynthetic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR014030 Beta-ketoacyl synthase, N-terminal
IPR014031 Beta-ketoacyl synthase, C-terminal
IPR016039 Thiolase-like
IPR020841 Polyketide synthase, beta-ketoacyl synthase domain

PFAM

PF00109
PF02801

PRINTS

PIRSF

SMART

SM00825

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NWU1