Version 5.4
Homo sapiens Protein: KHK
Summary
InnateDB Protein IDBP-36860.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KHK
Protein Name ketohexokinase (fructokinase)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000260599
InnateDB Gene IDBG-36852 (KHK)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Fructosuria (FRUCT) [MIM:229800]: Benign defect of intermediary metabolism. {ECO:0000269PubMed:7833921}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004454 ketohexokinase activity
GO:0005524 ATP binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006001 fructose catabolic process
GO:0044281 small molecule metabolic process
GO:0046835 carbohydrate phosphorylation
GO:0070873 regulation of glycogen metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR011611 Carbohydrate kinase PfkB
IPR029056 Ribokinase-like
PFAM PF00294
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P50053
PhosphoSite PhosphoSite-P50053
TrEMBL
UniProt Splice Variant
Entrez Gene 3795
UniGene Hs.567297
RefSeq NP_000212
HUGO HGNC:6315
OMIM 614058
CCDS CCDS1734
HPRD 11774
IMGT
EMBL AC013403 AJ005168 BC006233 CH471053 CR456801 X78677 X78678 Y09336 Y09340 Y09341
GenPept AAH06233 AAX93167 CAA06409 CAA55346 CAA55347 CAA70516 CAA70521 CAA70522 CAA70523 CAG33082 EAX00643

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca