Homo sapiens Protein: LRRC70
Summary
InnateDB Protein IDBP-368610.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC70
Protein Name leucine rich repeat containing 70
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000399441
InnateDB Gene IDBG-23487 (LRRC70)
Protein Structure
UniProt Annotation
Function Renders cells highly sensitive to the activation by cytokines and lipopolysaccharide (LPS). {ECO:0000269PubMed:12767927}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed at low levels in many tissues, including smooth muscle, brain, uterus, pancreas, cartilage, adipose, spleen and testis. {ECO:0000269PubMed:12767927}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
PFAM PF01463
PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART SM00082
SM00369
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7Z2Q7
PhosphoSite PhosphoSite-Q7Z2Q7
TrEMBL
UniProt Splice Variant
Entrez Gene 100130733
UniGene Hs.721348
RefSeq NP_852607
HUGO HGNC:35155
OMIM
CCDS CCDS47218
HPRD
IMGT
EMBL AK123022 AY280614 AY358733 CH471137
GenPept AAP36706 AAQ89095 BAC85517 EAW51382