InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AGRP

Summary

InnateDB Protein

IDBP-36877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGRP

Protein Name

agouti related protein homolog (mouse)

Synonyms

AGRT; ART; ASIP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000290953

InnateDB Gene

IDBG-36875 (AGRP)

Protein Structure

UniProt Annotation

Function

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. {ECO:0000250, ECO:0000269PubMed:10371151, ECO:0000269PubMed:11145747, ECO:0000269PubMed:15927146, ECO:0000269PubMed:17041250, ECO:0000269PubMed:9892020}.

Subcellular Localization

Secreted {ECO:0000269PubMed:15927146}. Golgi apparatus lumen {ECO:0000269PubMed:15927146}.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005184	neuropeptide hormone activity

Biological Process

GO:0007218	neuropeptide signaling pathway
GO:0007631	feeding behavior
GO:0008343	adult feeding behavior
GO:0009648	photoperiodism
GO:0009755	hormone-mediated signaling pathway
GO:0032868	response to insulin
GO:0042755	eating behavior
GO:0060135	maternal process involved in female pregnancy
GO:0060259	regulation of feeding behavior
GO:2000253	positive regulation of feeding behavior