Version 5.4
Homo sapiens Protein: CPPED1
Summary
InnateDB Protein IDBP-368842.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPPED1
Protein Name calcineurin-like phosphoesterase domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000411127
InnateDB Gene IDBG-15139 (CPPED1)
Protein Structure
UniProt Annotation
Function Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. {ECO:0000269PubMed:23799035, ECO:0000269PubMed:23939394}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:23799035}.
Disease Associations
Tissue Specificity Expressed in subcutaneous adipose tissue. {ECO:0000269PubMed:23939394}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0046872 metal ion binding
Biological Process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR029052 Metallo-dependent phosphatase-like
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRF8
PhosphoSite PhosphoSite-Q9BRF8
TrEMBL
UniProt Splice Variant
Entrez Gene 55313
UniGene Hs.609058
RefSeq NP_001092925
HUGO HGNC:25632
OMIM 615603
CCDS CCDS42119
HPRD 07735
IMGT
EMBL AC010333 AC092324 AC109597 AK002013 AK022710 AK298662 AY553877 BC006289 BX640805
GenPept AAH06289 AAS64575 BAA92034 BAB14194 BAG60830 CAE45887

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca