InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EOMES

Summary

InnateDB Protein

IDBP-368931.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EOMES

Protein Name

eomesodermin

Synonyms

TBR2;

Species

Homo sapiens

Ensembl Protein

ENSP00000388620

InnateDB Gene

IDBG-23119 (EOMES)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001706	endoderm formation
GO:0001707	mesoderm formation
GO:0001714	endodermal cell fate specification
GO:0001824	blastocyst development
GO:0001829	trophectodermal cell differentiation
GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007420	brain development
GO:0010002	cardioblast differentiation
GO:0010468	regulation of gene expression
GO:0019827	stem cell maintenance
GO:0021772	olfactory bulb development
GO:0021796	cerebral cortex regionalization
GO:0021895	cerebral cortex neuron differentiation
GO:0030154	cell differentiation
GO:0032609	interferon-gamma production
GO:0035914	skeletal muscle cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045664	regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050767	regulation of neurogenesis
GO:0060706	cell differentiation involved in embryonic placenta development
GO:0060809	mesodermal to mesenchymal transition involved in gastrulation