Version 5.4
Homo sapiens Protein: MTHFR
Summary
InnateDB Protein IDBP-369037.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MTHFR
Protein Name methylenetetrahydrofolate reductase (NAD(P)H)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000405082
InnateDB Gene IDBG-89655 (MTHFR)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity
Biological Process
GO:0006555 methionine metabolic process
GO:0035999 tetrahydrofolate interconversion
GO:0055114 oxidation-reduction process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003171 Methylenetetrahydrofolate reductase
IPR029041 FAD-linked oxidoreductase-like
PFAM PF02219
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9NY63
UniProt Splice Variant
Entrez Gene 4524
UniGene Hs.737916
RefSeq
HUGO HGNC:7436
OMIM 607093
CCDS
HPRD 06158
IMGT
EMBL AF398930 AJ249275 AL953897 AY046560 AY046561 AY046563 AY046564 AY046565
GenPept AAL17646 AAL17647 AAL17649 AAL17650 AAL17651 AAN40864 CAB81551

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca