InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PARN

Summary

InnateDB Protein

IDBP-369091.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PARN

Protein Name

poly(A)-specific ribonuclease

Synonyms

DAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000410525

InnateDB Gene

IDBG-15347 (PARN)

Protein Structure

UniProt Annotation

Function

3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. {ECO:0000269PubMed:10882133, ECO:0000269PubMed:11359775, ECO:0000269PubMed:12748283, ECO:0000269PubMed:15175153, ECO:0000269PubMed:9736620}.

Subcellular Localization

Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:10640832, ECO:0000269PubMed:9736620}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0004518	nuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006402	mRNA catabolic process
GO:0007292	female gamete generation
GO:0009451	RNA modification
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001374 Single-stranded nucleic acid binding R3H
IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain
IPR014789 Poly(A)-specific ribonuclease, RNA-binding

PFAM

PF01424
PF04857
PF08675

PRINTS

PIRSF

SMART

SM00393

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O95453