InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOXA2

Summary

InnateDB Protein

IDBP-369092.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOXA2

Protein Name

forkhead box A2

Synonyms

HNF3B; TCF3B;

Species

Homo sapiens

Ensembl Protein

ENSP00000400341

InnateDB Gene

IDBG-59234 (FOXA2)

Protein Structure

UniProt Annotation

Function

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:14500912}. Cytoplasm {ECO:0000269PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0000433	negative regulation of transcription from RNA polymerase II promoter by glucose
GO:0001701	in utero embryonic development
GO:0001705	ectoderm formation
GO:0001708	cell fate specification
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008344	adult locomotory behavior
GO:0009653	anatomical structure morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0010719	negative regulation of epithelial to mesenchymal transition
GO:0016568	chromatin modification
GO:0019216	regulation of lipid metabolic process
GO:0019218	regulation of steroid metabolic process
GO:0021533	cell differentiation in hindbrain
GO:0021904	dorsal/ventral neural tube patterning
GO:0023019	signal transduction involved in regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0030324	lung development
GO:0031018	endocrine pancreas development
GO:0032525	somite rostral/caudal axis specification
GO:0033132	negative regulation of glucokinase activity
GO:0040019	positive regulation of embryonic development
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045087	innate immune response (InnateDB)
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045945	positive regulation of transcription from RNA polymerase III promoter
GO:0048468	cell development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048665	neuron fate specification
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060487	lung epithelial cell differentiation
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448	connective tissue development
GO:0070741	response to interleukin-6
GO:0071542	dopaminergic neuron differentiation
GO:0090009	primitive streak formation
GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin
GO:2000543	positive regulation of gastrulation
GO:2000971	negative regulation of detection of glucose
GO:2000976	regulation of transcription from RNA polymerase II promoter involved in detection of glucose